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Berberine can have its own GI side effects (diarrhea, nausea) that compound with GLP-1 side effects

The fibrinogen level decrease observed in the Cohort 2 LCLT group reflects previous reporting of decreased plasma fibrinogen levels in hemodialysis patients who received LC supplementation (21)

Metabolism promotion synergy: at the cellular level, Meglutide activates the relevant metabolic pathways in adipocytes, liver cells and skeletal muscle cells, driving enhanced lipolysis metabolism, prompting the decomposition of triglycerides into free fatty acids and transferring them to the mitochondria for efficient oxidization and energy supply

Moser also suspects that this change in taste might also affect appetite, but his research didn't find a link between those whose taste buds change and those who lost more weight on the medications